Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.34 |
| ▸ | JAK1 | P23458 | 8/20 | 0.34 |
| ▸ | TYK2 | P29597 | 7/20 | 0.34 |
| ▸ | JAK3 | P52333 | 7/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31246471 | 1.00 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28701328 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28701327 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29608035 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29609559 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL28720145 | 0.89 | MAP4K1 (0.69) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL29930100 | 0.86 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858702 | 0.82 | MAP4K1 (1.00) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL22858703 | 0.82 | MAP4K1 (1.00) | MAP4K1CYP3A4JAK2JAK1TYK2 | |
| SCHEMBL22858712 | 0.82 | MAP4K1 (1.00) | MAP4K1CYP3A4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-B | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-10-18 | — | — | CN | disclosed |