SCHEMBL28720262

SCHEMBL28720262

C=C(c1ccc(F)cc1)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
POLB P06746 3/20 0.43
KMT2A Q03164 3/20 0.42
MEN1 O00255 1/20 0.42
RPS6KA2 Q15349 1/20 0.42
CASP3 P42574 1/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA9 Q16790 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
CA2 P00918 1/20 0.39
SCN2A Q99250 1/20 0.39
LMNA P02545 1/20 0.39
GLA P06280 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29612028 1.00 ALDH1A1 (0.43) ALDH1A1POLBKMT2AMEN1RPS6KA2
SCHEMBL28721465 0.85 ALDH1A1 (0.45) ALDH1A1POLBKMT2AMEN1CA12
SCHEMBL29612031 0.85 ALDH1A1 (0.45) ALDH1A1POLBKMT2AMEN1CA12
SCHEMBL28722564 0.84 CYP1A2 (0.46) ALDH1A1POLBKMT2AMEN1RPS6KA2
SCHEMBL29612186 0.84 CYP1A2 (0.46) ALDH1A1POLBKMT2AMEN1RPS6KA2
SCHEMBL28722307 0.82 KMT2A (0.50) ALDH1A1POLBKMT2AMEN1RAB9A
SCHEMBL29612348 0.82 KMT2A (0.50) ALDH1A1POLBKMT2AMEN1RAB9A
SCHEMBL31047664 0.80 POLB (0.47) ALDH1A1POLBKMT2AMEN1RPS6KA2
SCHEMBL29612033 0.78 NPC1 (0.56) ALDH1A1KMT2ARPS6KA2CASP3NPC1
SCHEMBL28724340 0.78 NPC1 (0.56) ALDH1A1KMT2ARPS6KA2CASP3NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114380733-B Chiral beta-amino acid derivative and preparation method thereof 常州大学 2024-01-26 CN disclosed
CN-114380733-A Chiral beta-amino acid derivative and preparation method thereof 常州大学 2022-04-22 CN disclosed