Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16861845 | 0.85 | NR4A2 (0.39) | DYRK1AABL1PIM1ALDH1A1KDM4E | |
| SCHEMBL16861761 | 0.74 | NR4A2 (0.40) | DYRK1APIM1ALDH1A1KDM4E | |
| SCHEMBL17841023 | 0.73 | NR4A2 (0.39) | DYRK1APIM1ALDH1A1KDM4E | |
| SCHEMBL28723961 | 0.73 | CSNK2A1 (0.47) | DYRK1BDYRK1AFGFR1FLT1KDR | |
| SCHEMBL16861659 | 0.73 | DYRK1A (0.36) | DYRK1BDYRK1AAURKADAPK3JAK2 | |
| SCHEMBL18224508 | 0.72 | DYRK1A (0.46) | DYRK1BDYRK1AAURKADAPK3JAK2 | |
| SCHEMBL16861810 | 0.72 | PARP1 (0.43) | DHODHDYRK1BDYRK1AAURKADAPK3 | |
| SCHEMBL31661343 | 0.70 | GABRP (0.35) | HAVCR2DYRK1APRKAA1KDM4CKDM5A | |
| SCHEMBL20164978 | 0.70 | GPR17 (0.43) | DHODHSORT1JAK2CDK9CDK5 | |
| SCHEMBL16861621 | 0.69 | GABRP (0.51) | DYRK1BDYRK1AAURKADAPK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558871-B | Tricyclic compounds as anticancer agents | 百时美施贵宝公司 | 2022-02-18 | — | — | CN | disclosed |