Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 3/20 | 0.65 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29637455 | 0.93 | STS (0.60) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL29676710 | 0.93 | STS (0.60) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL21114942 | 0.93 | STS (0.60) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL3413600 | 0.88 | STS (0.56) | STSGPR119KDM4EPKMJAK2 | |
| SCHEMBL1879011 | 0.84 | STS (0.63) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL28978008 | 0.83 | SMN1; SMN2 (0.62) | GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20137861 | 0.83 | STS (0.68) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL26107017 | 0.83 | STS (0.51) | STSGPR119KDM4EPKMGAA | |
| SCHEMBL27146441 | 0.83 | STS (0.62) | STSGPR119KDM4EPKMTGFBR1 | |
| SCHEMBL1875061 | 0.81 | GPR119 (0.56) | STSGPR119KDM4EPKMTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697989-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| WO-2022171118-A1 | COMPOUND HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF | 石药集团中奇制药技术（石家庄）有限公司 | 2022-08-18 | — | — | WO | disclosed |
| CN-110312717-B | Substituted fused heteroaromatic tricyclic compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2022-04-12 | — | — | CN | disclosed |