Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28737044 | 1.00 | DYRK3 (0.41) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL17891944 | 0.89 | ADK (0.36) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL19991474 | 0.88 | FLT3 (0.55) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL15220933 | 0.80 | ADK (0.37) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL29546608 | 0.77 | DYRK3 (0.39) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL15486867 | 0.77 | DYRK3 (0.39) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL28996748 | 0.76 | DYRK3 (0.37) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL15490997 | 0.76 | DYRK3 (0.35) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL28737052 | 0.76 | DYRK3 (0.35) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL15220893 | 0.76 | DYRK3 (0.35) | DYRK3ROCK2PRKD3MAP4K4PHKG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848634-B | Pyrimido [5,4-b ] pyridine compounds, optical isomers, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-07-07 | — | — | CN | disclosed |
| CN-114478547-A | Solid form bruton's tyrosine kinase inhibitor compounds and uses thereof | 上海润石医药科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478548-A | Application of Bruton's tyrosine kinase inhibitor | 上海润石医药科技有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-111848634-A | Pyrimido [5,4-b ] pyridine compound, optical isomer thereof, preparation method and application | 中国科学院上海药物研究所 | 2020-10-30 | — | — | CN | disclosed |