Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873829 | 0.88 | KDM4E (0.35) | AAK1XDHKDM4EALDH1A1GAA | |
| SCHEMBL2872949 | 0.79 | KDM4E (0.36) | AAK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL2873807 | 0.79 | AAK1 (0.35) | AAK1MAPTSMN1; SMN2HTTGCGR | |
| SCHEMBL2870191 | 0.78 | PTGES (0.31) | — | |
| SCHEMBL2866756 | 0.73 | SMN1; SMN2 (0.36) | AAK1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2875445 | 0.70 | AAK1 (0.39) | AAK1HTTGCGRTDP1 | |
| SCHEMBL6753981 | 0.67 | AAK1 (0.45) | AAK1ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2872637 | 0.66 | AAK1 (0.36) | AAK1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL23227712 | 0.66 | CBFB (0.45) | KDM4EMAPTRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL2874738 | 0.65 | PTGES (0.35) | KDM4EALDH1A1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103306-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIVARAL AGENTS | ASTRAZENECA UK LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |