Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 5/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738374 | 1.00 | SPPL2A (0.59) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738371 | 1.00 | SPPL2A (0.59) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738369 | 0.94 | SPPL2A (0.68) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738367 | 0.94 | SPPL2A (0.68) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738312 | 0.87 | SPPL2A (0.51) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738314 | 0.87 | SPPL2A (0.51) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28610516 | 0.87 | SPPL2A (0.64) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28610517 | 0.87 | SPPL2A (0.64) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28628358 | 0.84 | SPPL2A (0.60) | SPPL2AKEAP1 | |
| SCHEMBL28738327 | 0.84 | SPPL2A (0.60) | SPPL2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230630-A | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2022-03-25 | — | — | CN | disclosed |