Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738312 | 1.00 | SPPL2A (0.51) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738367 | 0.87 | SPPL2A (0.68) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738371 | 0.87 | SPPL2A (0.59) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738369 | 0.87 | SPPL2A (0.68) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738372 | 0.87 | SPPL2A (0.59) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL28738374 | 0.87 | SPPL2A (0.59) | SPPL2AMMP3PSEN1PSEN2APH1B | |
| SCHEMBL14390723 | 0.74 | SPPL2A (0.54) | SPPL2AF2HTTCSNK1E | |
| SCHEMBL4373559 | 0.74 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4911140 | 0.74 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23129692 | 0.74 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230630-A | Triptolide derivative and application thereof | 郑州人民医院(郑州人民医院医疗管理中心) | 2022-03-25 | — | — | CN | disclosed |