Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 known ✓ | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 known ✓ | P35228 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.73 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.39 |
| ▸ | GGT1 | P19440 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cysteine SCHEMBL6112869 | 0.95 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL6112867 | 0.95 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL27613026 | 0.93 | PTGS1 (0.84) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL28253736 | 0.91 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL6244287 | 0.91 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL6244297 | 0.91 | PTGS1 (0.80) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL27709351 | 0.91 | — | — | |
| Cysteine SCHEMBL27709352 | 0.91 | — | — | |
| Cysteine SCHEMBL28253746 | 0.88 | PTGS1 (0.76) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 | |
| Cysteine SCHEMBL1195723 | 0.88 | PTGS1 (0.84) | PTGS1SLC7A11SLC7A5ENPEPGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1709233-A | Lyophiliced powder containing tiprenolol and its preparing method | QIAO JIE (CN) | 2005-12-21 | — | — | CN | disclosed |