SCHEMBL2875474

SCHEMBL2875474

CC(O[Si](C)(C)C(C)(C)C)C(CCc1ccccc1)n1cnc2c(Cl)ncnc21

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CDK2 P24941 1/20 0.39
CCNB3 Q8WWL7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11899618 1.00 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL11899549 0.88
SCHEMBL11899223 0.87 FLT4 (0.41)
SCHEMBL1741649 0.86 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL11900412 0.86 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL11899186 0.86 ADA (0.39) CCNB2CDK1CCNB1CCNB3
SCHEMBL1741185 0.83 ADA (0.48) CCNB2CDK1CCNB1CCNB3
SCHEMBL1741162 0.82 ADA (0.50) CCNB2CDK1CCNB1CCNB3
SCHEMBL1740481 0.82 ADA (0.50) CCNB2CDK1CCNB1CCNB3
SCHEMBL1740457 0.74 ADORA2A (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010084300-A2 STEM CELL CULTURE METHODS ITI SCOTLAND LIMITED (GB) 2010-07-29 WO disclosed