SCHEMBL1741649

SCHEMBL1741649

C[C@H]([C@H](CCc1ccccc1)O[Si](C)(C)C(C)(C)C)n1cnc2c(Cl)ncnc21

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CDK2 P24941 1/20 0.39
CCNB3 Q8WWL7 1/20 0.39
TYMP P19971 1/20 0.36
FGFR1 P11362 2/20 0.36
FGFR4 P22455 2/20 0.36
MEN1 O00255 1/20 0.35
NR2F2 P24468 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11900412 1.00 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL1740463 0.88 ADORA2A (0.47)
SCHEMBL1740457 0.88 ADORA2A (0.47)
SCHEMBL11899822 0.87 FLT4 (0.41) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL11899641 0.87 FLT4 (0.41) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL2875474 0.86 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL11899618 0.86 CCNB2 (0.39) CCNB2CDK1CCNB1CDK2CCNB3
SCHEMBL1741202 0.86 PDE2A (0.36) CCNB2CDK1CCNB1CCNB3FGFR1
SCHEMBL1741206 0.86 PDE2A (0.36) CCNB2CDK1CCNB1CCNB3FGFR1
SCHEMBL1741157 0.86 PDE2A (0.36) CCNB2CDK1CCNB1CCNB3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120202287-A1 Stem Cell Culture Methods ITI SCOTLAND LIMITED (GB) 2012-08-09 US disclosed
EP-2389436-A2 STEM CELL CULTURE METHODS ITI Scotland Limited (GB) 2011-11-30 EP disclosed
US-20110257911-A1 SYSTEMS AND METHODS FOR DETECTING CHANGES IN ENERGY USAGE IN A BUILDING JOHNSON CONTROLS TECHNOLOGY COMPANY 2011-10-20 US disclosed
WO-2010084300-A2 STEM CELL CULTURE METHODS ITI SCOTLAND LIMITED (GB) 2010-07-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202287-A1 Stem Cell Culture Methods KIT, SOX18, MCL1 CCNB2 73/4885CDK1 103/4885CCNB1 77/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.