Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049169 | 0.87 | SIGMAR1 (0.61) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL5087578 | 0.85 | SIGMAR1 (0.64) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL11020642 | 0.85 | SIGMAR1 (0.64) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL7392307 | 0.85 | SIGMAR1 (0.64) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL2440428 | 0.85 | SLC18A3 (0.60) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL11300310 | 0.85 | SIGMAR1 (0.58) | SIGMAR1SLC18A3CCR5EPHX1MEN1 | |
| SCHEMBL7419921 | 0.85 | SLC18A3 (0.60) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL9133642 | 0.85 | SLC18A3 (0.60) | SIGMAR1SLC18A3CCR5EPHX1EPHX2 | |
| SCHEMBL18435050 | 0.83 | SIGMAR1 (0.61) | SIGMAR1SLC18A3CCR5EPHX1OPRM1 | |
| SCHEMBL7103234 | 0.83 | SLC18A3 (0.62) | SIGMAR1SLC18A3CCR5OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427430-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127452-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2010-11-11 | — | — | WO | disclosed |