Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.95 |
| ▸ | RAF1 | P04049 | 2/20 | 0.83 |
| ▸ | EGFR | P00533 | 12/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.80 |
| ▸ | SRC | P12931 | 2/20 | 0.78 |
| ▸ | GAK | O14976 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382750 | 0.91 | MAP2K1 (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6384880 | 0.89 | MAP2K1 (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6381609 | 0.89 | EGFR (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6381535 | 0.88 | EGFR (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6381446 | 0.88 | EGFR (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6381926 | 0.88 | MAP2K1 (0.76) | MAP2K1EGFRERBB2SRCGAK | |
| SCHEMBL6383704 | 0.88 | EGFR (0.78) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL5733290 | 0.88 | MAP2K1 (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6381464 | 0.88 | EGFR (1.00) | MAP2K1RAF1EGFRERBB2SRC | |
| SCHEMBL6380423 | 0.88 | EGFR (1.00) | MAP2K1EGFRERBB2SRCGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100432071-C | Substituted 1H-indole-2-ketone compound and its preparation method and uses | SHANGHAI INST MATERIA MEDICA (CN) | 2008-11-12 | — | — | CN | disclosed |
| CN-1769284-A | Substituted 1H-indole-2-ketone compound and its preparation method and uses | SHANGHAI INST MATERIA MEDICA (CN) | 2006-05-10 | — | — | CN | disclosed |