Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 8/20 | 1.00 |
| ▸ | EGFR | P00533 | 8/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.80 |
| ▸ | SRC | P12931 | 5/20 | 0.79 |
| ▸ | RAF1 | P04049 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381609 | 0.89 | EGFR (1.00) | MAP2K1EGFRERBB2SRCRAF1 | |
| SCHEMBL6380121 | 0.88 | EGFR (0.83) | MAP2K1EGFRERBB2SRC | |
| SCHEMBL6381535 | 0.88 | EGFR (1.00) | MAP2K1EGFRERBB2SRCRAF1 | |
| SCHEMBL6381464 | 0.88 | EGFR (1.00) | MAP2K1EGFRERBB2SRCRAF1 | |
| SCHEMBL28756490 | 0.88 | MAP2K1 (0.95) | MAP2K1EGFRERBB2SRCRAF1 | |
| SCHEMBL6380423 | 0.88 | EGFR (1.00) | MAP2K1EGFRERBB2SRC | |
| SCHEMBL6379990 | 0.87 | MAP2K1 (0.77) | MAP2K1EGFRERBB2SRC | |
| SCHEMBL6381511 | 0.86 | EGFR (0.77) | MAP2K1EGFRERBB2SRC | |
| SCHEMBL6382822 | 0.86 | MAP2K1 (0.78) | MAP2K1EGFRERBB2SRCRAF1 | |
| SCHEMBL6382185 | 0.86 | MAP2K1 (1.00) | MAP2K1EGFRERBB2SRCRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178967-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| EP-1584619-A1 | Derivatives of quinoline as inhibitors for MEK | AstraZeneca AB (SE) | 2005-10-12 | — | — | EP | disclosed |
| EP-1178967-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068201-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |