Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240083 | 0.94 | VCAM1 (0.72) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9412619 | 0.91 | VCAM1 (0.60) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1983624 | 0.87 | VCAM1 (0.62) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11001741 | 0.86 | VCAM1 (0.66) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6929407 | 0.86 | KMT2A (0.69) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1981879 | 0.85 | VCAM1 (0.60) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11219158 | 0.85 | VCAM1 (0.64) | VCAM1ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL11703945 | 0.83 | TSHR (0.49) | ALDH1A1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6740307 | 0.83 | VCAM1 (0.70) | VCAM1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4175676 | 0.83 | VCAM1 (0.70) | VCAM1ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066628-B1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2010-10-20 | — | — | EP | disclosed |
| CN-101495449-A | 2-phenyl-indoles as prostaglandin D2 receptor antagonists | SANOFI AVENTIS (FR) | 2009-07-29 | — | — | CN | disclosed |
| US-20090176804-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2009-07-09 | — | — | US | disclosed |
| EP-2066628-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008014186-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |
| US-20070265278-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2007-11-15 | — | — | US | disclosed |
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20070208036-A1 | Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-09-06 | — | — | US | disclosed |
| US-7230001-B1 | Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-06-12 | — | — | US | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |
| US-4704391-A | Pyridazinones, and pharmaceutical preparations thereof | CIBA-GEIGY CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| US-4654340-A | Pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |
| US-4624951-A | Substituted pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
| US-4613599-A | Method of treating thrombotic disease with pyridazinones | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0172141-A1 | Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use | CIBA-GEIGY AG (CH) | 1986-02-19 | — | — | EP | disclosed |
| EP-0059688-B1 | PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1985-05-15 | — | — | EP | disclosed |
| EP-0059688-A1 | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use | CIBA-GEIGY AG (CH) | 1982-09-08 | — | — | EP | disclosed |
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | disclosed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |
| EP-0001051-A2 | Derivatives of benzenesulfonamide, method for their preparation and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208036-A1 | Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them | ARRB1, NPY1R, ADRB3 | VCAM1 1486/4885ALDH1A1 425/4885MEN1 1691/4885 |
| US-20070265278-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | PTGDR2, PTGDR, CYSLTR2 | VCAM1 1778/4885ALDH1A1 1779/4885MEN1 4654/4885 |
| US-20090176804-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, CYSLTR2 | VCAM1 454/4885ALDH1A1 1757/4885MEN1 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.