Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.54 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RARB | P10826 | 3/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octane SCHEMBL28824317 | 0.93 | KAT8 (0.62) | KAT8PPARAPPARGTSHRALDH1A1 | |
| SCHEMBL9420871 | 0.93 | KAT8 (0.62) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Cyclohexane SCHEMBL27580700 | 0.92 | KAT8 (0.58) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Pentane SCHEMBL27636475 | 0.92 | KAT8 (0.60) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Thiazolidine SCHEMBL28228791 | 0.88 | PPARA (0.47) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Octane SCHEMBL28857502 | 0.88 | KAT8 (0.62) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Hexane SCHEMBL28050986 | 0.88 | KAT8 (0.62) | KAT8PPARAPPARGTSHRALDH1A1 | |
| SCHEMBL182437 | 0.88 | KAT8 (0.62) | KAT8PPARAPPARGTSHRALDH1A1 | |
| Naphthalene SCHEMBL27271514 | 0.87 | TSHR (0.57) | KAT8PPARAPPARGTSHRALDH1A1 | |
| SCHEMBL27857274 | 0.87 | TSHR (0.57) | KAT8PPARAPPARGTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101249091-A | Target for therapy of cognitive impairment | UNIV JOHNS HOPKINS (US) | 2008-08-27 | — | — | CN | disclosed |
| CN-101249090-A | Target for theraphy of cognitive impairment | UNIV JOHNS HOPKINS (US) | 2008-08-27 | — | — | CN | disclosed |
| CN-1829804-A | Target sites for treatment of cognitive dysfunction | UNIV JOHNS HOPKINS (US) | 2006-09-06 | — | — | CN | disclosed |