Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628245 | 0.80 | — | — | |
| SCHEMBL18607993 | 0.78 | HSD11B1 (0.36) | ALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL8430009 | 0.74 | — | — | |
| SCHEMBL2038268 | 0.74 | — | — | |
| Tert-Butyl Formate SCHEMBL28118470 | 0.73 | TDP1 (0.52) | TDP1KDM4EALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27993042 | 0.73 | TDP1 (0.43) | TDP1KDM4EALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27621319 | 0.72 | TDP1 (0.50) | TDP1 | |
| Tert-Butyl Formate SCHEMBL28320938 | 0.71 | TDP1 (0.54) | TDP1 | |
| Tert-Butyl Formate SCHEMBL27975581 | 0.70 | TDP1 (0.59) | TDP1 | |
| Tert-Butyl Formate SCHEMBL27710891 | 0.70 | TDP1 (0.52) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509798-C | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prevention and treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-1823056-A | Trisubstituted aryl and heteroaryl derivatives as modulatorsof metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARM INC (US) | 2006-08-23 | — | — | CN | disclosed |