Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 4/20 | 0.34 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PNLIP | P16233 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12356955 | 0.82 | KCNK3 (0.39) | APPCNR2ALPLF11HTR2A | |
| SCHEMBL28755485 | 0.82 | HRH4 (0.37) | APPALPLSLC6A4 | |
| SCHEMBL6445833 | 0.82 | EPAS1 (0.34) | APPCNR2CYP11B1CYP11B2ANO1 | |
| SCHEMBL16957725 | 0.80 | CNR2 (0.35) | APPCNR2ANO1ALPLF11 | |
| SCHEMBL20303532 | 0.80 | PDE2A (0.42) | APPCNR2ANO1ALPLF11 | |
| SCHEMBL19262097 | 0.80 | CNR2 (0.38) | APPCNR2ANO1ALPLF11 | |
| SCHEMBL27643654 | 0.78 | ANO1 (0.34) | APPCNR2CYP11B1CYP11B2ANO1 | |
| SCHEMBL27624241 | 0.78 | KCNK3 (0.44) | APPCYP11B1CYP11B2SLC6A4KCNH2 | |
| SCHEMBL32682742 | 0.75 | CNR2 (0.40) | CNR2ALPLTNNI3KF11 | |
| SCHEMBL20303378 | 0.75 | CNR2 (0.40) | CNR2ALPLTNNI3KF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100395234-C | Novel CB1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | CN | disclosed |
| CN-101012193-A | Novel CB 1 receptour inverse agonists | HOFFMANN LA ROCHE (CH) | 2007-08-08 | — | — | CN | disclosed |
| CN-1735593-A | Novel CB1 receptor inverse agonists | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |