Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 6/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAP2 | P11137 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | PNLIP | P16233 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6442565 | 0.83 | MAOA (0.37) | ALPLEPHX2 | |
| SCHEMBL28758201 | 0.82 | APP (0.37) | ALPLCNR2ANO1FFAR4CYP11B1 | |
| SCHEMBL27643654 | 0.81 | ANO1 (0.34) | EPAS1ALPLCNR2ANO1FFAR4 | |
| SCHEMBL3637979 | 0.80 | ALDH1A1 (0.40) | — | |
| SCHEMBL5608059 | 0.78 | KCNK3 (0.38) | FFAR4CYP11B1CYP11B2 | |
| SCHEMBL5758153 | 0.77 | HTR2A (0.38) | FFAR4MAP2HTR2AHTR2C | |
| SCHEMBL12356955 | 0.76 | KCNK3 (0.39) | ALPLCNR2APPHTR2AHTR2C | |
| SCHEMBL26664767 | 0.75 | TDP1 (0.35) | EPAS1 | |
| SCHEMBL6443959 | 0.75 | TDP1 (0.35) | EPAS1 | |
| SCHEMBL16958565 | 0.75 | ALPL (0.33) | EPAS1ALPLCNR2ANO1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |