SCHEMBL28758971

SCHEMBL28758971

NCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.65
ADORA2B P29275 3/20 0.65
ADORA3 P0DMS8 3/20 0.64
ADORA1 P30542 3/20 0.64
SLC29A1 Q99808 3/20 0.64
MAPK1 P28482 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
DPP4 P27487 1/20 0.64
MEN1 O00255 1/20 0.64
SLC28A1 O00337 1/20 0.64
MAP3K7 O43318 1/20 0.64
SLC28A2 O43868 1/20 0.64
GAPDH P04406 1/20 0.64
STAT6 P42226 1/20 0.64
PI4KA P42356 1/20 0.64
KMT2A Q03164 1/20 0.64
PI4K2B Q8TCG2 1/20 0.64
DOT1L Q8TEK3 1/20 0.64
PI4K2A Q9BTU6 1/20 0.64
SLC28A3 Q9HAS3 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30208555 0.93 ADORA2A (0.60) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL29387907 0.92 ADORA2A (0.61) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL451885 0.92 ADORA2A (0.61) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL451884 0.92 ADORA2A (0.61) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL24920112 0.92 ADORA2A (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL30208521 0.92 ADORA2A (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL28872479 0.91 ADORA2A (0.64) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL31307310 0.90 SLC29A1 (0.67) ADORA2AADORA2BSLC29A1
SCHEMBL28477260 0.89 ADORA2A (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL6474066 0.88 SLC29A1 (0.68) ADORA2AADORA2BSLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109843915-B Genetically engineered cell and preparation method thereof 朱诺治疗学股份有限公司 2023-03-03 CN disclosed
CN-115698278-A Compositions comprising Cas12i2 variant polypeptides and uses thereof 阿伯生物技术公司 2023-02-03 CN disclosed
CN-114502204-A RNA combinations and compositions with reduced immunostimulatory properties 库尔维科公司 2022-05-13 CN disclosed