SCHEMBL28477260

SCHEMBL28477260

NC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.67
ADORA2B P29275 3/20 0.67
ADORA3 P0DMS8 3/20 0.67
ADORA1 P30542 3/20 0.67
SLC29A1 Q99808 3/20 0.67
MAPK1 P28482 2/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
DPP4 P27487 1/20 0.67
MEN1 O00255 1/20 0.67
SLC28A1 O00337 1/20 0.67
MAP3K7 O43318 1/20 0.67
SLC28A2 O43868 1/20 0.67
GAPDH P04406 1/20 0.67
STAT6 P42226 1/20 0.67
PI4KA P42356 1/20 0.67
KMT2A Q03164 1/20 0.67
PI4K2B Q8TCG2 1/20 0.67
DOT1L Q8TEK3 1/20 0.67
PI4K2A Q9BTU6 1/20 0.67
SLC28A3 Q9HAS3 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenosine SCHEMBL28471756 0.95 ADORA3 (0.77) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL28872479 0.91 ADORA2A (0.64) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL28894286 0.89 SLC29A1 (0.65) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL28758971 0.89 ADORA2A (0.65) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL24920112 0.89 ADORA2A (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL30208521 0.89 ADORA2A (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL155836 0.89 SLC29A1 (0.75) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL31286196 0.89 ADORA3 (0.67) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL155837 0.89 SLC29A1 (0.75) ADORA2AADORA2BADORA3ADORA1SLC29A1
SCHEMBL15865951 0.87 BMPR1B (0.68) ADORA2AADORA2BSLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114829940-A Methods, kits and compositions for diagnosing and treating kidney disease 希尔氏宠物营养品公司 2022-07-29 CN disclosed
CN-111406216-A Compounds, reagents and uses thereof 麦特博隆股份有限公司 2020-07-10 CN disclosed