Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.73 |
| ▸ | BRAF | P15056 | 10/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.70 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.70 |
| ▸ | RAF1 | P04049 | 5/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28759802 | 0.95 | BRAF (0.72) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL29723022 | 0.95 | BRAF (0.72) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL29723231 | 0.93 | BRAF (0.82) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL28759820 | 0.93 | BRAF (0.82) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL28759806 | 0.89 | KDR (0.73) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL29722991 | 0.89 | KDR (0.73) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL29722983 | 0.87 | KDR (0.67) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL28759810 | 0.87 | KDR (0.67) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL30447746 | 0.86 | KDR (0.69) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL28759809 | 0.86 | BRAF (0.72) | KDRBRAFMAPK14TNNI3KRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621140-B | Aryldifluoroacetamide compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-08-11 | — | — | CN | disclosed |
| CN-114621140-A | Aryl difluoro acetamide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-06-14 | — | — | CN | disclosed |