Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.72 |
| ▸ | RAF1 | P04049 | 6/20 | 0.72 |
| ▸ | KDR | P35968 | 11/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28759810 | 0.91 | KDR (0.67) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL29722983 | 0.91 | KDR (0.67) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL28759811 | 0.89 | BRAF (0.71) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL28464514 | 0.86 | BRAF (0.72) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL29723231 | 0.86 | BRAF (0.82) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL28759820 | 0.86 | BRAF (0.82) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL28759806 | 0.86 | KDR (0.73) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28759793 | 0.86 | KDR (0.73) | BRAFRAF1KDREGFRMAPK14 | |
| SCHEMBL29722991 | 0.86 | KDR (0.73) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL1012329 | 0.84 | BRAF (1.00) | BRAFRAF1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621140-B | Aryldifluoroacetamide compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-08-11 | — | — | CN | disclosed |
| CN-114621140-A | Aryl difluoro acetamide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-06-14 | — | — | CN | disclosed |