Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.52 |
| ▸ | FLT3 | P36888 | 16/20 | 0.52 |
| ▸ | KIT | P10721 | 15/20 | 0.52 |
| ▸ | FLT1 | P17948 | 7/20 | 0.45 |
| ▸ | CSF1R | P07333 | 6/20 | 0.45 |
| ▸ | LCK | P06239 | 4/20 | 0.45 |
| ▸ | FYN | P06241 | 4/20 | 0.45 |
| ▸ | LYN | P07948 | 4/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.45 |
| ▸ | BLK | P51451 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FER | P16591 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27657330 | 0.89 | KDR (0.47) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL3398443 | 0.88 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657403 | 0.88 | KDR (0.53) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27636420 | 0.87 | KDR (0.53) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657319 | 0.84 | KDR (0.55) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657318 | 0.80 | KDR (0.51) | KDRFLT3KITMET | |
| SCHEMBL422243 | 0.80 | KDR (0.57) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657343 | 0.80 | KDR (0.51) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27636562 | 0.79 | KDR (0.56) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657281 | 0.78 | KDR (0.47) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |