Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.57 |
| ▸ | FLT3 | P36888 | 14/20 | 0.57 |
| ▸ | KIT | P10721 | 14/20 | 0.57 |
| ▸ | FLT1 | P17948 | 7/20 | 0.57 |
| ▸ | CSF1R | P07333 | 6/20 | 0.57 |
| ▸ | TEK | Q02763 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | FYN | P06241 | 4/20 | 0.53 |
| ▸ | LYN | P07948 | 4/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | BLK | P51451 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27657403 | 0.92 | KDR (0.53) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657281 | 0.90 | KDR (0.47) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL5251524 | 0.89 | KDR (0.50) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL6805276 | 0.86 | FLT3 (0.66) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL425760 | 0.83 | KDR (0.67) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL3398443 | 0.83 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL5307685 | 0.83 | KDR (0.58) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL27657448 | 0.81 | KDR (0.61) | KDRFLT3KITMET | |
| SCHEMBL27636370 | 0.80 | IKBKE (0.67) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL28760137 | 0.80 | KDR (0.52) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299243-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120022253-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-01-26 | — | — | US | disclosed |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022253-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KDR 724/4885FLT3 41/4885KIT 361/4885 |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABL1, MAP3K19, MAP3K1 | KDR 800/4885FLT3 41/4885KIT 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.