Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.57 |
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP10 | P09238 | 5/20 | 0.52 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 3/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930061 | 0.91 | MMP13 (0.65) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL27683257 | 0.87 | MMP13 (0.57) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4936750 | 0.86 | MAPT (0.61) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4936756 | 0.86 | MMP13 (0.62) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4935373 | 0.85 | MMP13 (0.57) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4934669 | 0.83 | MMP13 (0.63) | MMP13MMP2MMP10MMP8 | |
| SCHEMBL27683266 | 0.83 | MMP13 (0.53) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL27683269 | 0.81 | MMP13 (0.67) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL4932534 | 0.81 | MMP13 (0.67) | MMP13MMP2MMP10MMP8MMP3 | |
| SCHEMBL8194790 | 0.81 | MMP13 (0.60) | MMP13MMP2MMP10MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101351453-A | Heterocyclic amide compound and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2009-01-21 | — | — | CN | disclosed |
| CN-1976907-A | Heterocyclic amide compound and use thereof as an MMP-13 inhibitor | TAKEDA PHARMACEUTICAL (JP) | 2007-06-06 | — | — | CN | disclosed |