Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387583 | 0.87 | GPR119 (0.64) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL2881232 | 0.87 | GPR119 (0.61) | GPR119CYP4F2CYP4A11GPR183 | |
| SCHEMBL2881112 | 0.85 | GPR119 (0.53) | GPR119CYP4F2CYP4A11GPR183 | |
| SCHEMBL384653 | 0.85 | GPR119 (0.67) | GPR119GPR183 | |
| SCHEMBL2881607 | 0.83 | GPR119 (0.58) | GPR119CYP4F2CYP4A11GPR183 | |
| SCHEMBL386535 | 0.80 | GPR119 (0.65) | GPR119GPR183 | |
| SCHEMBL3841477 | 0.79 | GPR119 (0.54) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL871667 | 0.78 | GPR119 (0.63) | GPR119CYP4F2CYP4A11GPR183 | |
| SCHEMBL3983967 | 0.78 | GPR119 (0.58) | GPR119CYP4F2CYP4A11GPR183 | |
| SCHEMBL14191013 | 0.77 | GPR119 (0.65) | GPR119CYP4F2CYP4A11GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010512334-A | — | — | 2010-04-22 | — | — | JP | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | claimed |