Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269734 | 0.92 | HDAC2 (0.57) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27679562 | 0.90 | FPR2 (0.54) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27659497 | 0.87 | HDAC8 (0.57) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27679616 | 0.86 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27681824 | 0.83 | HDAC8 (0.55) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27659483 | 0.83 | FPR2 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL28760351 | 0.83 | HDAC8 (0.64) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL28760350 | 0.82 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27679547 | 0.82 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27659484 | 0.81 | MAPK1 (0.54) | HDAC8HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997627-A | Histone deacetylase inhibitors | MERCK & CO INC (US) | 2007-07-11 | — | — | CN | claimed |
| CN-1997627-A | Histone deacetylase inhibitors | MERCK & CO INC (US) | 2007-07-11 | — | — | CN | disclosed |