Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877167 | 1.00 | PPARG (0.47) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2834249 | 0.86 | AURKA (0.53) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2834247 | 0.86 | AURKA (0.53) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2173141 | 0.84 | AURKA (0.54) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2173145 | 0.84 | AURKA (0.54) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2174102 | 0.74 | AURKA (0.66) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2174106 | 0.74 | AURKA (0.66) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2172001 | 0.74 | AURKA (0.55) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2171996 | 0.74 | AURKA (0.55) | PPARGAURKAMTORPRKAG1PRKAA1 | |
| SCHEMBL2170994 | 0.73 | AKR1B1 (0.57) | PPARGAURKAMTORPRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254576-A1 | ANDROGEN RECEPTOT-ABLATIVE AGENTS | The Ohio State University Research Foundation (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009105621-A1 | ANDROGEN RECEPTOT-ABLATIVE AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-08-27 | — | — | WO | disclosed |