Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766524 | 0.95 | SMN1; SMN2 (0.42) | SMN1; SMN2GAAMEN1KMT2AMAPT | |
| SCHEMBL29721683 | 0.76 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL840476 | 0.75 | MAPT (0.66) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL29721450 | 0.75 | GAA (0.43) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL9588005 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL30089775 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL4459931 | 0.71 | MAPT (0.51) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL9589544 | 0.70 | FLT3 (0.39) | SMN1; SMN2 | |
| SCHEMBL29722013 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2MEN1KMT2AMAPTHPGD | |
| SCHEMBL3021566 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2MEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114656486-B | Purinone compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-114656486-A | Purine ketone compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-06-24 | — | — | CN | disclosed |