Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | ASPH | Q12797 | 7/20 | 1.00 |
| ▸ | KDM8 | Q8N371 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875877 | 1.00 | KDM4E (1.00) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL13444610 | 0.80 | KDM4E (0.66) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL2880402 | 0.79 | KDM4E (1.00) | KDM4EASPHKDM8MAPTALDH1A1 | |
| SCHEMBL2871383 | 0.76 | KDM4E (0.62) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL2871381 | 0.76 | KDM4E (0.62) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL10515386 | 0.76 | KDM4E (0.62) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL453183 | 0.76 | AKR1C3 (0.68) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL6748839 | 0.75 | KDM4E (0.60) | KDM4EASPHKDM8MEN1KMT2A | |
| SCHEMBL2875066 | 0.75 | KDM4E (0.66) | KDM4EASPHKDM8KMT2AMAPT | |
| SCHEMBL22720165 | 0.75 | KDM4E (0.60) | KDM4EASPHKDM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |