Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 1.00 |
| ▸ | ASPH | Q12797 | 11/20 | 0.64 |
| ▸ | KDM8 | Q8N371 | 11/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879347 | 0.83 | KDM4E (0.71) | KDM4EASPHKDM8MAPTHTT | |
| SCHEMBL2875066 | 0.80 | KDM4E (0.66) | KDM4EASPHKDM8MAPK8MAPT | |
| SCHEMBL2877327 | 0.79 | KDM4E (1.00) | KDM4EASPHKDM8MAPTALDH1A1 | |
| SCHEMBL2875877 | 0.79 | KDM4E (1.00) | KDM4EASPHKDM8MAPTALDH1A1 | |
| SCHEMBL28289321 | 0.79 | KDM4E (0.64) | KDM4EMAPK8MAPTHTTCYP3A4 | |
| SCHEMBL29908900 | 0.76 | MAP2K1 (0.65) | KDM4EMAPK8MAPTHTTCXCL8 | |
| SCHEMBL16571766 | 0.76 | MAP2K1 (0.65) | KDM4EMAPK8MAPTHTTCXCL8 | |
| SCHEMBL9128060 | 0.74 | KDM4E (0.58) | KDM4EMAPK8MAPTHTTAURKA | |
| SCHEMBL9471929 | 0.74 | HTT (0.76) | KDM4EMAPK8MAPTHTTALDH1A1 | |
| SCHEMBL4256425 | 0.73 | FABP4 (0.65) | KDM4EMAPK8MAPTCYP3A4CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |