Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 8/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778620 | 0.91 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778616 | 0.91 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4ALDH1A1 | |
| SCHEMBL28778631 | 0.86 | MTOR (0.36) | JAK1JAK3JAK2CYP3A4USP2 | |
| SCHEMBL28778600 | 0.84 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778532 | 0.83 | JAK1 (0.43) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28944378 | 0.83 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778598 | 0.83 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778723 | 0.82 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778536 | 0.81 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778533 | 0.81 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114698370-A | Compounds and methods for treating cytokine release syndrome | 里格尔药品股份有限公司 | 2022-07-01 | — | — | CN | disclosed |