Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.41 |
| ▸ | JAK3 | P52333 | 15/20 | 0.41 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778532 | 0.89 | JAK1 (0.43) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778536 | 0.89 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778723 | 0.88 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778538 | 0.87 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778533 | 0.84 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778598 | 0.84 | JAK1 (0.41) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778616 | 0.84 | JAK1 (0.42) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778515 | 0.83 | JAK1 (0.38) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778576 | 0.83 | JAK1 (0.40) | JAK1JAK3JAK2CYP3A4SYK | |
| SCHEMBL28778610 | 0.83 | JAK1 (0.40) | JAK1JAK3JAK2CYP3A4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114698370-A | Compounds and methods for treating cytokine release syndrome | 里格尔药品股份有限公司 | 2022-07-01 | — | — | CN | disclosed |