Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770982 | 1.00 | CTSK (0.46) | CTSKJAK3BTKCKS1BSKP1 | |
| SCHEMBL23657173 | 0.84 | BTK (0.42) | CTSKJAK3BTKCKS1BSKP1 | |
| SCHEMBL24183332 | 0.84 | JAK3 (0.41) | CTSKJAK3BTKKCNA3PDE10A | |
| SCHEMBL22389722 | 0.83 | JAK3 (0.40) | CTSKJAK3BTKCKS1BSKP1 | |
| SCHEMBL28779238 | 0.81 | CKS1B (0.42) | JAK3BTKCKS1BSKP1SKP2 | |
| SCHEMBL23657226 | 0.81 | CKS1B (0.42) | JAK3BTKCKS1BSKP1SKP2 | |
| SCHEMBL29771164 | 0.81 | CKS1B (0.42) | JAK3BTKCKS1BSKP1SKP2 | |
| SCHEMBL22389965 | 0.80 | RET (0.40) | JAK3BTKRET | |
| SCHEMBL22389936 | 0.79 | JAK3 (0.35) | CTSKJAK3BTK | |
| SCHEMBL22389941 | 0.79 | JAK3 (0.35) | CTSKJAK3BTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114761394-B | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115916765-A | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-114761394-A | Pyridine or pyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2022-07-15 | — | — | CN | disclosed |