SCHEMBL28779338

SCHEMBL28779338

CCCCc1n[nH]c(C(F)(F)F)c1C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 8/20 0.47
HCAR3 P49019 2/20 0.41
GABRP O00591 1/20 0.36
GABRD O14764 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRB1 P18505 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
GABRA2 P47869 1/20 0.36
GABRB2 P47870 1/20 0.36
GABRA4 P48169 1/20 0.36
GABRE P78334 1/20 0.36
GABRA6 Q16445 1/20 0.36
GABRG1 Q8N1C3 1/20 0.36
GABRG3 Q99928 1/20 0.36
GABRQ Q9UN88 1/20 0.36
DPP4 P27487 1/20 0.36
ALDH1A1 P00352 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7470965 0.91 HCAR2 (0.39) HCAR2HCAR3DPP4ALDH1A1
SCHEMBL27758480 0.87 HCAR2 (0.36) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL21393 0.79 HCAR2 (0.37) HCAR2HCAR3DPP4
SCHEMBL27499626 0.78 HCAR2 (0.47) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL28036518 0.76 HCAR2 (0.46) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL27737815 0.76 HCAR2 (0.54) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL27737479 0.76 HCAR2 (0.46) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL9115479 0.74 HCAR2 (0.55) HCAR2HCAR3DPP4ALDH1A1KDM4E
SCHEMBL27758252 0.74 HCAR2 (0.44) HCAR2HCAR3GABRPGABRDGABRA1
SCHEMBL11035220 0.73 HCAR2 (0.46) HCAR2HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101405270-B Pyrazoles as 11-beta-HSD-1 HOFFMANN LA ROCHE 2013-01-16 CN claimed
CN-101405270-A Pyrazoles as 11-beta-HSD-1 HOFFMANN LA ROCHE (CH) 2009-04-08 CN claimed
CN-101405270-B Pyrazoles as 11-beta-HSD-1 HOFFMANN LA ROCHE 2013-01-16 CN disclosed
CN-101405270-A Pyrazoles as 11-beta-HSD-1 HOFFMANN LA ROCHE (CH) 2009-04-08 CN disclosed