Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PTAFR | P25105 | 2/20 | 0.64 |
| ▸ | NAMPT | P43490 | 5/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628250 | 0.87 | NPSR1 (0.67) | KMT2ANPC1NAMPTGAAMAPT | |
| SCHEMBL30491866 | 0.87 | NPSR1 (0.67) | KMT2ANPC1NAMPTGAAMAPT | |
| SCHEMBL8239123 | 0.85 | MEN1 (0.81) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL27781492 | 0.85 | HDAC2 (0.75) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL1972631 | 0.84 | HDAC2 (0.71) | HDAC2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL4662136 | 0.84 | RAB9A (0.83) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL1584859 | 0.80 | KMT2A (0.77) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL5210141 | 0.80 | HDAC2 (0.67) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL14470323 | 0.79 | PTAFR (0.51) | HDAC2HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL506616 | 0.79 | NAMPT (0.67) | HDAC2HDAC8HDAC6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101501035-B | Pyrimidine derivatives as PI3K inhibitors and uses thereof | CHUGAI PHARMACEUTICAL CO LTD | 2013-01-23 | — | — | CN | disclosed |
| CN-101501035-A | Pyrimidine derivatives as P13K inhibitors and uses thereof | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |