Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 6/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 9/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.54 |
| ▸ | PRKACA | P17612 | 7/20 | 0.54 |
| ▸ | PRKACG | P22612 | 7/20 | 0.54 |
| ▸ | PRKACB | P22694 | 7/20 | 0.54 |
| ▸ | LIMK2 | P53671 | 10/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297068 | 0.81 | LIMK2 (0.81) | LIMK1ROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL1446615 | 0.74 | LIMK2 (0.63) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL28780125 | 0.73 | LIMK1 (0.63) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL28780124 | 0.72 | LIMK2 (0.71) | LIMK1ROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL4776438 | 0.72 | AKT1 (0.64) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4301992 | 0.72 | LIMK2 (0.84) | LIMK1ROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL4154204 | 0.72 | TACR1 (0.49) | — | |
| SCHEMBL2715524 | 0.72 | LIMK2 (0.76) | LIMK1ROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL4782383 | 0.71 | AKT1 (0.61) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL1446787 | 0.71 | LIMK2 (0.77) | LIMK1ROCK2PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101565420-B | Limk2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC | 2015-05-20 | — | — | CN | disclosed |
| CN-101565420-A | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2009-10-28 | — | — | CN | disclosed |