Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.61 |
| ▸ | KHK | P50053 | 1/20 | 0.50 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27782474 | 0.78 | LIMK1 (0.62) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL1446615 | 0.78 | LIMK2 (0.63) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL27782481 | 0.75 | LIMK1 (0.58) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL4780087 | 0.75 | AKT1 (0.51) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL1050760 | 0.72 | AKT1 (0.56) | AKT1KHK | |
| SCHEMBL28780125 | 0.72 | LIMK1 (0.63) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL12959143 | 0.72 | AKT1 (0.56) | AKT1LIMK2LIMK1 | |
| SCHEMBL12958072 | 0.72 | AKT1 (0.57) | AKT1LIMK2LIMK1ROCK2PRKACA | |
| SCHEMBL4869496 | 0.71 | LIMK2 (0.72) | AKT1KHKLIMK2 | |
| SCHEMBL28780100 | 0.71 | AKT1 (0.54) | AKT1LIMK2LIMK1ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2008012635-A2 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051419-A1 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | CCNY, CCND2, CCND1 | AKT1 752/4885KHK 2207/4885LIMK2 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.