Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1598249 | 0.90 | PIK3CD (0.49) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL4174724 | 0.84 | PIK3CD (0.52) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL13973985 | 0.84 | PIK3CD (0.49) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL1598282 | 0.84 | MAPT (0.48) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL13973986 | 0.79 | MAPT (0.48) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL4169571 | 0.79 | MAPT (0.48) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL1599020 | 0.78 | KDM4E (0.44) | PIK3CDRAB9AMAPTMGAMGAA | |
| SCHEMBL1598069 | 0.74 | ALDH1A1 (0.40) | PIK3CDRAB9AGAAKMT2AKDM4E | |
| SCHEMBL4173738 | 0.73 | PIK3CD (0.47) | PIK3CDRAB9AMAPTMAPK1MGAM | |
| SCHEMBL14047376 | 0.72 | KDM4E (0.44) | PIK3CDRAB9AMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101715453-B | Heterocyclic compounds and their uses | AMGEN INC | 2012-06-27 | — | — | CN | disclosed |
| CN-101715453-A | Heterogeneous ring compound and application thereof | AMGEN INC | 2010-05-26 | — | — | CN | disclosed |