SCHEMBL28786353

SCHEMBL28786353

Cc1nccnc1-c1nn2c(=O)cc(-c3ccc(OC(c4ccccc4)C(F)(F)F)cc3)[nH]c2c1C(=O)N1CC(CF)C1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.31
PLAT P00750 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24834762 1.00 PDE10A (0.31) PDE10APLAT
SCHEMBL24834881 1.00 PDE10A (0.31) PDE10APLAT
SCHEMBL29785485 1.00 PDE10A (0.31) PDE10APLAT
SCHEMBL29785438 0.90
SCHEMBL24834811 0.90
SCHEMBL29785689 0.90
SCHEMBL24834792 0.90
SCHEMBL28786386 0.87 KDR (0.32)
SCHEMBL23415398 0.87 PLAT (0.35) PDE10APLAT
SCHEMBL24835002 0.87 PLAT (0.39) PLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114786778-A Therapeutic compounds 基因泰克公司 2022-07-22 CN claimed
CN-114786778-A Therapeutic compounds 基因泰克公司 2022-07-22 CN disclosed