Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.39 |
| ▸ | JAK3 | P52333 | 9/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27826835 | 0.90 | SYK (0.40) | JAK2SYKAURKBKCNH2AOC3 | |
| SCHEMBL27806069 | 0.86 | ZAP70 (0.40) | SYK | |
| SCHEMBL27805955 | 0.81 | SYK (0.45) | JAK2JAK3PTK2SYKAURKB | |
| SCHEMBL27827067 | 0.81 | JAK2 (0.45) | JAK2JAK3SYK | |
| SCHEMBL27805867 | 0.81 | JAK2 (0.49) | JAK2JAK3PTK2PTGS2 | |
| SCHEMBL27806245 | 0.79 | JAK2 (0.49) | JAK2JAK3PTK2AURKB | |
| SCHEMBL28790576 | 0.79 | SYK (0.39) | JAK2JAK3PTK2SYK | |
| SCHEMBL3360211 | 0.78 | JAK2 (0.41) | JAK2JAK3PTK2SYKMTOR | |
| SCHEMBL28790460 | 0.78 | SYK (0.41) | JAK2SYKAURKB | |
| SCHEMBL27806023 | 0.77 | SYK (0.41) | JAK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101990539-A | Compounds and compositions as kinase inhibitors | IRM LLC | 2011-03-23 | — | — | CN | claimed |