Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.41 |
| ▸ | JAK3 | P52333 | 10/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.41 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359888 | 0.85 | ZAP70 (0.41) | SYK | |
| SCHEMBL3361081 | 0.80 | SYK (0.48) | JAK2JAK3PTK2SYK | |
| SCHEMBL3362308 | 0.80 | JAK2 (0.46) | JAK2SYK | |
| SCHEMBL1049029 | 0.79 | ZAP70 (0.55) | JAK2JAK3PTK2 | |
| SCHEMBL28787115 | 0.78 | JAK2 (0.39) | JAK2JAK3PTK2SYKPTGS2 | |
| SCHEMBL3358764 | 0.77 | SYK (0.42) | JAK2SYKMTOR | |
| SCHEMBL3359025 | 0.76 | SYK (0.42) | JAK2JAK3PTK2SYK | |
| SCHEMBL3361332 | 0.76 | SYK (0.49) | JAK2JAK3PTK2SYK | |
| SCHEMBL3359805 | 0.76 | ZAP70 (0.42) | JAK2SYK | |
| SCHEMBL3362709 | 0.75 | SYK (0.45) | SYKSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |