Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27806063 | 0.83 | ZAP70 (0.43) | ZAP70FGFR1FGFR4KDRJAK3 | |
| SCHEMBL3362887 | 0.82 | ZAP70 (0.46) | ZAP70FGFR1FGFR4KDRJAK3 | |
| SCHEMBL1048324 | 0.78 | ZAP70 (0.72) | ZAP70SYK | |
| SCHEMBL3361199 | 0.77 | ZAP70 (0.37) | ZAP70 | |
| SCHEMBL27826732 | 0.75 | RET (0.43) | ZAP70KDREGFRSYK | |
| SCHEMBL3388909 | 0.75 | ACP1 (0.41) | JAK3LCKEGFRSYK | |
| SCHEMBL3359883 | 0.75 | FGFR1 (0.34) | ZAP70FGFR1FGFR4KDRJAK3 | |
| SCHEMBL27826756 | 0.74 | ZAP70 (0.53) | ZAP70JAK3LCKALKBTK | |
| SCHEMBL3390137 | 0.74 | ZAP70 (0.36) | ZAP70KDRBTKSYK | |
| SCHEMBL3362586 | 0.73 | ZAP70 (0.44) | ZAP70JAK3JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101990539-A | Compounds and compositions as kinase inhibitors | IRM LLC | 2011-03-23 | — | — | CN | disclosed |