Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360691 | 0.84 | INSR (0.41) | ZAP70MAP4K1JAK2JAK3PTK2 | |
| SCHEMBL27805895 | 0.82 | ZAP70 (0.43) | ZAP70MAP4K1JAK2JAK3PTK2 | |
| SCHEMBL3359744 | 0.81 | CYP1A2 (0.53) | ZAP70JAK2LRRK2 | |
| SCHEMBL3362139 | 0.81 | SYK (0.48) | ZAP70MAP4K1JAK2 | |
| SCHEMBL27826756 | 0.80 | ZAP70 (0.53) | ZAP70JAK3BRD4CREBBP | |
| SCHEMBL1047400 | 0.77 | ZAP70 (0.73) | ZAP70MAP4K1JAK2JAK3PTK2 | |
| SCHEMBL3362816 | 0.74 | ZAP70 (0.41) | ZAP70JAK2JAK3PTK2BRD4 | |
| SCHEMBL27806144 | 0.74 | ZAP70 (0.38) | ZAP70MAP4K1JAK2JAK3PTK2 | |
| SCHEMBL3392301 | 0.74 | RET (0.41) | ZAP70MAP4K1JAK2JAK3PTK2 | |
| SCHEMBL3388909 | 0.74 | ACP1 (0.41) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |