Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 10/20 | 0.60 |
| ▸ | BACE1 | P56817 | 10/20 | 0.60 |
| ▸ | BCHE | P06276 | 7/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27791660 | 0.86 | BCHE (0.54) | MEN1KMT2APOLBACHEBACE1 | |
| SCHEMBL2498286 | 0.84 | ACHE (0.73) | MEN1KMT2APOLBACHEBACE1 | |
| Hydrochloric Acid SCHEMBL2766858 | 0.83 | ACHE (0.71) | MEN1KMT2APOLBACHEBACE1 | |
| SCHEMBL28787947 | 0.80 | ACHE (0.61) | MEN1KMT2APOLBACHEBACE1 | |
| SCHEMBL6505462 | 0.78 | CCR8 (0.70) | MEN1KMT2APOLBACHEBACE1 | |
| SCHEMBL12652356 | 0.77 | MEN1 (0.71) | MEN1KMT2APOLBACHEBACE1 | |
| SCHEMBL7504191 | 0.76 | BCHE (0.75) | ACHEBACE1BCHE | |
| SCHEMBL1908453 | 0.76 | BCHE (0.75) | ACHEBACE1BCHE | |
| SCHEMBL1781710 | 0.76 | BCHE (0.75) | ACHEBACE1BCHE | |
| SCHEMBL8487979 | 0.76 | ACHE (0.69) | MEN1KMT2APOLBACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101842366-A | Azacyclylisoquinolinone and azacyclylisoindolone derivatives as histamine-3 antagonists | WYETH CORP | 2010-09-22 | — | — | CN | disclosed |