Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14132099 | 0.78 | CYP2A13 (0.57) | CYP2A13HSD17B10CYP2C9ALOX15ALDH1A1 | |
| SCHEMBL14514792 | 0.75 | CYP2A13 (0.63) | DRD2DRD4HRH2HRH1DRD3 | |
| SCHEMBL260363 | 0.75 | CYP2C9 (0.53) | HTTCYP2A13HSD17B10CYP2C9ALOX15 | |
| SCHEMBL10782490 | 0.74 | CYP2A13 (0.61) | DRD2DRD4HRH2HRH1DRD3 | |
| SCHEMBL12683586 | 0.73 | LMNA (0.53) | HTTSMN1; SMN2DRD2DRD4HRH2 | |
| SCHEMBL13726528 | 0.73 | MEN1 (0.72) | HTTSMN1; SMN2DRD2DRD4HRH2 | |
| SCHEMBL11225310 | 0.73 | CHRM2 (0.63) | HTTSMN1; SMN2DRD2HRH1DRD3 | |
| SCHEMBL21587706 | 0.72 | KDM4E (0.64) | HTTSMN1; SMN2TSHRALDH1A1KDM4E | |
| SCHEMBL260803 | 0.71 | CYP2C9 (0.45) | CYP2A13HSD17B10CYP2C9ALOX15KDM4E | |
| SCHEMBL10894451 | 0.71 | CYP2D6 (0.62) | DRD2DRD4HRH2HRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101987848-B | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing the same | SERVIER LAB | 2014-06-18 | — | — | CN | disclosed |
| CN-101987848-A | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB | 2011-03-23 | — | — | CN | disclosed |