SCHEMBL28790764

SCHEMBL28790764

Nc1ccc(C2CCCN2c2ccc(F)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
MAPK1 P28482 2/20 0.50
MAPT P10636 2/20 0.50
GFER P55789 2/20 0.50
HTT P42858 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
NR3C2 P08235 1/20 0.50
TRPA1 O75762 3/20 0.46
TSHR P16473 1/20 0.42
PTBP1 P26599 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
JAK2 O60674 1/20 0.40
JAK3 P52333 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6963115 0.87 NR3C2 (0.48) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL23623856 0.81 KDM4E (0.54) NR3C2TRPA1KDM4E
SCHEMBL4543080 0.77 NR3C2 (0.65) ALDH1A1MAPTTDP1NR3C2TRPA1
SCHEMBL4129691 0.77 NR3C2 (0.52) MAPTNR3C2TRPA1JAK2JAK3
SCHEMBL1982307 0.77 ALDH1A1 (0.56) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL1982996 0.77 ALDH1A1 (0.56) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL1987454 0.77 ALDH1A1 (0.56) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL15876393 0.77 ALDH1A1 (0.56) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL4777399 0.75 SLC6A2 (0.40) ALDH1A1LMNAMAPK1MAPTGFER
SCHEMBL15458234 0.75 NR3C2 (0.45) ALDH1A1LMNAMAPK1MAPTGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103819459-B Anti-Viral Compounds 艾伯维巴哈马有限公司 2017-05-17 CN disclosed
CN-102333772-A Antiviral compounds ABBOTT LAB 2012-01-25 CN disclosed