Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | GRK5 | P34947 | 13/20 | 0.70 |
| ▸ | GRK2 | P25098 | 7/20 | 0.70 |
| ▸ | FLT3 | P36888 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386826 | 0.90 | MET (0.71) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2386137 | 0.86 | GRK5 (0.73) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2384060 | 0.85 | MET (1.00) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL29351419 | 0.85 | MET (1.00) | METKCNH2GRK5GRK2FLT3 | |
| Hydrochloric Acid SCHEMBL2748533 | 0.84 | MET (1.00) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2386041 | 0.83 | MET (0.70) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2749562 | 0.82 | MAP4K3 (0.59) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL23083217 | 0.82 | GRK5 (1.00) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL23083286 | 0.82 | GRK5 (1.00) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL13577796 | 0.82 | GRK5 (0.85) | METKCNH2GRK5GRK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910158-A | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders | ASTRAZENECA AB | 2010-12-08 | — | — | CN | disclosed |