Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 12/20 | 0.46 |
| ▸ | UBA3 | Q8TBC4 | 12/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782852 | 1.00 | NAE1 (0.46) | NAE1UBA3CRHR1 | |
| SCHEMBL782936 | 0.91 | NAE1 (0.47) | NAE1UBA3CRHR1 | |
| SCHEMBL782935 | 0.91 | NAE1 (0.47) | NAE1UBA3CRHR1 | |
| SCHEMBL782494 | 0.90 | NAE1 (0.60) | NAE1UBA3 | |
| SCHEMBL782666 | 0.87 | CRHR1 (0.35) | NAE1UBA3CRHR1 | |
| SCHEMBL783671 | 0.86 | NAE1 (0.57) | NAE1UBA3 | |
| SCHEMBL782789 | 0.86 | NAE1 (0.57) | NAE1UBA3 | |
| SCHEMBL2873770 | 0.83 | NAE1 (0.51) | NAE1UBA3CRHR1 | |
| SCHEMBL2873765 | 0.83 | NAE1 (0.51) | NAE1UBA3CRHR1 | |
| SCHEMBL783955 | 0.83 | CRHR1 (0.36) | NAE1UBA3CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049491-B1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARM INC (US) | 2010-10-20 | — | — | EP | disclosed |